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To control for the effects of the hormonal manipulations in this protocol, we will also recruit a group of asymptomatic controls who are either currently on ET or were prescribed ET previously and with no previous history of perimenopause-related depression or HRT-induced dysphoria.

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These changes are enhanced during the reproductive age and then become less pronounced after the menopause, as estradiol levels decline.

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As well as being produced by the gonads, in both genders fat cells produce active estradiol precursors, even in women who have gone through the menopause.

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Doctors would simply prescribe standard cold treatment X and pharmacists would then dispense the product combination and provide the necessary counselling to the patient.

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